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Part of a wave of research into the chemistry of the brain in recent decades, it sparked new investigations into many problems, one of them the chemical nature of drug addiction

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Key findings: Current cigarette use was strongly associated with frequent headache Former cigarette use also remained associated Current HTP use showed a modest but significant association The association was weaker for HTPs than cigarettes, but not absent While HTPs are often perceived as less harmful, they still deliver nicotine and other constituents, and may be associated with headache burden